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KMID : 0380620110430060675
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Korean Journal of Food Science and Technology
2011 Volume.43 No. 6 p.675 ~ p.682
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Monitoring of Anti-impotence Drugs and Their Analogues in Fo
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Lee Hyun-Sook
Lee Joon-Goo
Kim Jin-Chul
Oh Jae-Ho
Jang Young-Mi
Kim Mee-Hye
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Abstract
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This study was conducted to monitor the concentrations of 24 anti-impotence drugs and their analogues in various foods and dietary supplements, with the aim of ensuring the safety of the foods and supplements. The measurements were done in 226 samples using high performance liquid chromatography/photodiode array detector (HPLC/ PDA) and liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). Five male sexual function enhancing products have been detected as follows: acethylvardenafil (21,476 mg/kg; 15 mg/capsule from one sample), sildenafil (52,778 mg/kg, 29 mg/capsule in one sample; 71,535 mg/kg, 48 mg/capsule in one sample), and tadalafil (9,772-55,545 mg/kg, 6-33 mg/capsule in four samples). A sustainable monitoring of anti-impotence drugs and their analogues in various foods and dietary supplement is recommended.
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KEYWORD
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anti-impotence drugs, monitoring, food, HPLC/PDA, LC-ESI-MS/MS
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